Bio-Techne, a global life sciences company providing innovative tools and bioactive reagents for the research and clinical diagnostic communities, and Lunaphore, a Swiss life sciences company developing technology to enable spatial biology in every laboratory, announced a strategic partnership to develop the first fully automated spatial multiomics workflow with same-slide hyperplex detection of protein and RNA biomarkers. Designed to provide ultimate flexibility in panel design, the solution will allow researchers to easily combine well-characterized antibodies with gold-standard RNAscope in situ hybridization probes to illuminate changes in cell phenotypes and functional states across a wide range of diseases.
“Multiomics spatial imaging has the potential to transform our understanding of disease and accelerate the development of novel therapeutics and next generation diagnostics,” said Kim Kelderman, President of Bio-Techne’s Diagnostics and Genomics Segment. “Together with Lunaphore, we are excited to bring the power of next-generation spatial multiomics to the research community with a fully automated and scalable end-to-end solution delivering robust performance.”
The fully automated multiomics solution will utilize Lunaphore’s revolutionary multiplex sequential immunofluorescence (seqIF) solution portfolio including the COMET instrument and SPYRE Antibody Panels to provide unmatched tissue morphology, scalability, and reproducibility. Ideal for translational and clinical research applications, the COMET easily fits within the standard histology workflow to enable hyperplex protein detection at single-cell and subcellular resolution, leveraging existing libraries of non-conjugated primary antibodies.
RNAscope HiPlex technology will be included in the automated workflow to enable visualization of RNA biomarkers with industry leading single-molecule sensitivity and specificity. Backed by over 8,000 peer reviewed publications, RNAscope has enabled researchers around the world to uncover new breakthroughs across a wide range of different diseases including cancer, neurodegenerative, and immune mediated diseases. With over 45,000 catalog probes available and fast, expert custom probe design available for any gene or species, researchers will be able to easily design and execute novel multiomics panels to achieve their study goals.
“We are thrilled to announce this partnership with Bio-Techne. RNAscope has a very well-established place in spatial transcriptomics and the combination with Lunaphore’s fully automated spatial proteomics capabilities will bring an unmatched solution to researchers,” said Ata Tuna Ciftlik, CEO at Lunaphore. “The addition of RNAscope HiPlex capability into our recently announced COMET™ product suite will help researchers to truly streamline and automate spatial proteomic, transcriptomic, and multiomics assay workflows with push-button automation, eliminating existing manual upfront steps on all three modalities”.
An initial view of the proof-of-concept data demonstrating the capability of COMET to perform an automated same-slide multiomics assay using RNAscope will be shared by Ata Tuna Ciftlik this evening at the Lunaphore Dinner Symposium in association with the American Association for Cancer Research (AACR) Annual Meeting in Orlando, Florida.