Novartis receives approval for Cosentyx label update in Europe to include dosing flexibility in ankylosing spondylitis

Novartis announced that the European Commission (EC) has approved a label update for the up-titration of Cosentyx (secukinumab) to 300 mg for patients with active ankylosing spondylitis (AS).

The approval is based on data from MEASURE 3, a three-year study that explored the tolerability and efficacy of Cosentyx in patients with AS. Response rates were greater in the 300 mg dose group, particularly among patients with previous anti-TNF exposure, compared with the recommended 150 mg dose. The safety profile was consistent with previous studies.

“This approval gives rheumatologists more flexibility to ensure their patients are able to achieve the best response to treatment,” said Sam Khalil, Global Head of Medical Affairs Immunology, Hepatology and Dermatology at Novartis. “It further encourages our ongoing efforts to reimagine care to ensure all patients are able to experience full relief from the signs and symptoms of AS.”