Junshi Biosciences announced that it has recently signed a collaboration agreement with the Institute of Microbiology of the Chinese Academy of Sciences (IMCAS) to jointly develop neutralizing antibodies, a potential novel treatment for COVID-19.
Junshi Biosciences and IMCAS have been working together to explore innovative treatments for the novel coronavirus, COVID-19. Currently, they have obtained multiple strains of neutralizing antibodies (NAb) capable of effectively blocking viral invasion in laboratory assays and have conducted animal experiments. Preliminary in vitro and in vivo studies have verified the blocking activity of the NAb strains. It is in the process of verifying the preclinical toxicology and in vivo activity of the antibodies in order to file Investigative New Drug (IND) applications with domestic and overseas regulatory agencies.
A neutralizing antibody (NAb) is an antibody capable of keeping an infectious agent, usually a virus, from infecting a cell by neutralizing or inhibiting its biological effect. It could potentially facilitate virus clearance, altering the course of infection. Antibody-based therapies have several advantages: they can be therapeutic as well as prophylactic, protecting health workers in a high-risk environment; they are generally safe given their specificity to pathogen; and compared with the serum of recovered patients, antibodies are more consistent in quality and can be readily mass-produced through biological engineering, thereby ensuring ample clinical supply for the pandemic.
As a leading pharmaceutical innovator in China specialized in therapeutic antibody development, Junshi Biosciences has established long-term cooperation with IMCAS with its proprietary antibody development platform to carry out screening for various pathogen host receptors and anti-pathogen antibodies, from patients recovered from the infection. Since the very beginning of the COVID-19 outbreak, these two parties have been actively collaborating to combat the epidemic and develop neutralizing antibodies.
Dr. Ning Li, CEO of Junshi Biosciences, commented, “There has not yet been an effective antibody drug approved for treating the novel coronavirus in humans. It is our responsibility as a local pharmaceutical innovator to harness our proprietary antibody platform and R&D capabilities to diligently develop a treatment in the near-future. We believe our collaboration with IMCAS will help accelerate the clinical development of an antibody therapy. We look forward to facilitating the use of antibody-based therapy as a treatment option for COVID-19, both in China and globally.”