Hoth Therapeutics Partners with University of Cincinnati to Perform Critical Studies for Streamlined Development of Novel Antibiotic HT-006

Hoth Therapeutics, Inc. a biopharmaceutical company, today announced entering into a Research Agreement with the University of Cincinnati Research Institute (“UCRI”) to perform critical antimicrobial characterization studies with HT-006 as part of the streamlined drug development plan. HT-006 is a novel antibiotic under development as a potential treatment for multi-drug resistant bacterial lung infections, such as hospital-acquired pneumonia (HAP), cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD) and ventilator-associated pneumonia (VAP). Hoth previously licensed the HT-006 technology for commercial evaluation from the Walter Reed Army Institute of Research.

“We are pleased to commence a new research program with Dr. Hassett and the University of Cincinnati Research Institute,” said Robb Knie, CEO of Hoth Therapeutics. “There is a growing need for new antibiotic therapies targeted at multi-drug resistant bacteria, particularly for life-threatening conditions like HAP and VAP. The work to be conducted by Dr. Hassett will assist in expediting the HT-006 drug development program towards the clinic.”

The research will be led by Daniel Hassett, PhD, Professor in the University of Cincinnati College of Medicine, Department of Molecular Genetics, Biochemistry, and Microbiology. Dr. Hassett’s research has been focused on studying pathogenic mechanisms of multi-drug resistant bacteria and effective antimicrobial strategies to combat these organisms, commonly referred to as “superbugs”. Specifically, Dr. Hassett has targeted pathogenic mechanisms of Pseudomonas aeruginosa during chronic lung infections that occur in patients with each of the aforementioned diseases. Dr. Hassett was also recently identified in the prestigious Stanford University’s list of the top 2% of the world’s most cited scientists for 2020, has ~170 published papers and an h-index of 57.

The research plan includes critical antimicrobial in vitro characterization studies for HT-006 in alignment with the U.S. Food and Drug Administration’s (FDA) program for “antibacterial therapies for patients with an unmet medical need for the treatment of serious bacterial diseases.” This streamlined program allows for the use of nonclinical animal studies to reduce clinical studies required for approval.